» iNEXT: Infrastructure for NMR, EM and X-rays for Translational Research

iNEXT aims to translate fundamental structural biology research into bio-scientific applications. iNEXT…

Provides trans-national access to state-of-the-art infrastructures for structural biology.
iNEXT Access
Stimulates access for non-structural biologists.
iNEXT Access
Provides training to modern structural biology technology.
iNEXT Training

More specifically:

Data collection for macromolecular X-ray crystallography (MX), solution scattering (SAXS), Nuclear Magnetic Resonance (NMR), Electron Microscopy (EM), Macromolecular interactions and Advanced Light Microscopy (ALM).
iNEXT Access
Themes of access for expert users and non-structural biologists:
1. Structural Audit
2. Enhanced Support
3. High-End Data Collection
iNEXT Access
Strengthening links between industrial and academic structural biologists.
iNEXT Training
iNEXT Industry
Promoting drug development by enabling ligand fragment screening methods for the discovery of chemical probes and hits.

iNEXT internal biomedical research activities promote integration of the infrastructures and expansion to new communities

Structure-based small molecule inhibitor discovery (ligand screening).
Integrated study of membrane proteins.
Study of macromolecules and their complexes in cells.

iNEXT Joint Research Activities

Scientific Advisory Board

Bridget Carragher
Director Simons Electron Microscopy Center at New York Structural Biology Center
New York, USA
Johan Garssen
Professor Immunopharmacology at Utrecht University, Director Platform Immunology at Nutricia Research
Utrecht, The Netherlands
Astrid Gräslund
Professor of Biophysics at Stockholm University
Stockholm, Sweden
Jan Löwe
Deputy Director Medical Research Council – Laboratory of Molecular Biology (MRC-LMB)
Cambridge, United Kingdom
Ray Stevens
Provost Professor of Biological Sciences and Chemistry at University of Southern California, Director of the Bridge Institute
Los Angeles, USA

iNEXT for you!

iNEXT can support researchers from all EU and associated countries, but also (in a more limited capacity) from international labs, to perform a variety of structural biology experiments with a translational research component, in the fields of X-ray crystallography, SAXS, NMR, EM, light imaging and Biophysics for Macromolecular Interactions. Support includes all access costs to all facilities, and support for travel and accommodation for the duration of experiments, where applicable. We particularly encourage applications from people with no or limited experience to the different techniques to look at our Extended Support and Structural Audit modalities, as well as expert researchers that will be more interested in our High-End Data collection modalities.

Europe-wide network

The iNEXT consortium involves 23 partners from 14 different European countries. Training and networking activities are carried out to attract new users and to disseminate scientific results across academia and industry.

EU funding

Funded from the Horizon 2020 programme of the European Union, iNEXT (H2020 Grant # 653706) is the first research infrastructure project that combines access to different structural biology technologies (SAXS, X-ray crystallography, NMR, EM, biophysical characterization).

iNEXT: Infrastructure for NMR, EM and X-rays for Translational Research