The EMBL Outstation in Grenoble, France, is a laboratory of about 100 people whose activities include fundamental research, methods and instrumentation development and external user service provision (often via EU I3s) in the field of structural biology. The outstation shares the European Photon and Neutron (EPN) campus with the European Synchrotron Radiation Facility (ESRF), which produces some of the world’s most intense X-ray beams, the Institut Laue Langevin (ILL), which provides high-flux neutron beams and the French Institut de Biologie Structurale. The Outstation collaborates very closely with the ESRF in building and operating beamlines for macromolecular crystallography, in developing the associated diffraction instrumentation and techniques and in providing expertise to help external visitors. The highly automated ESRF crystallography beamlines are all equipped with EMBL-designed high-precision microdiffractometers and frozen crystal sample changers. A new X-ray small-angle scattering instrument run by ESRF and EMBL is now operational with a custom designed small-volume automatic sample changer. Other high-throughput methods have also been introduced. These include a very successful robotic platform for nanovolume crystallisation (one of the largest in Europe), a novel, high-throughput screening method, ESPRIT, which enables soluble protein domains to be identified in otherwise badly expressed or insoluble proteins and a Eukaryotic Expression Facility (EEF) specialising in the expression of multi-subunit complexes in insect cells, building on and developing further the well-known MultiBac method.
Click here for the website of the EMBL Grenoble and see below the people involved in iNEXT: