Poul Nissen’s research career is founded in structural biology, starting in the 1990’s with remarkable PhD studies of the EF-Tu:GTP:aminoacyl-tRNA ternary complex, and later, as a postdoc, of the ribosome in the laboratory of Nobel laureate Thomas A. Steitz. As an independent researcher his major activties over the last 10 years have been focused on the structure, function, mechanism and cell biologial function of cation transporting ATPases such as Na+,K+-ATPase, Ca2+-ATPase and Cu+-ATPase. He has published 17 peer-reviewed papers 17 in Nature, Science and Cell alone, and his papers have been cited more than 9500 times. His research has led to major breakthroughs of our understanding of P-type ATPases in health and disease, such as Na+,K+-ATPase mutations in neurological disorders and hypertension, Ca2+-ATPase in cardiovascular physiology and as a cancer drug target, Plasma membrane H+-ATPase as a target for novel antifungals, and Cu+-ATPase mutations associated with Menkes and Wilson’s diseases. Nissen is a very frequent speaker, chair and organiser of leading international meetings. He takes part in many collaborations in translational medicine and molecular medicine, with pharmaceutical and biotech industry, and also in start-up activities (e.g. pcovery.com)