In the context of iNEXT three Joint Research Activities are defined. Each JRA addresses contemporary methodological structural biology problems, namely:
(1) structure-guided drug discovery
(2) integral membrane systems
(3) in-cell structural biology
Each JRA involves different iNEXT partners that are best suited for a set of defined tasks. The ultimate goal of each JRA activity is to improve, both in quality and quantity, the integrated access services that iNEXT offers to users (iNEXT Access). Outcome of JRAs is described in Publications and protocols.
JRA1: Developing structure-guided drug discovery workflows
The goal is to develop technology and workflows to support Structure Guided Drug Design and Fragment Based Drug Design projects and to provide access to fragment screening and focused compound screening by building innovative and highly automated pipelines that can be offered as services to scientists in both industry and academia. These new services are already implemented as novel modalities of Trans-national Access.
JRA2: Enabling technologies for integral membrane protein systems
iNEXT aims to connect structural biology to translational research, specifically for the area of membrane proteins. Integral membrane proteins such as receptors, ion channels and transporters compose the most prolific class of drug targets today. Comprehensive structural analysis for use in drug discovery programs within clinical settings requires soluble, mono-disperse membrane protein preparations that maintain activity and provide robust biophysical and biochemical data. The structural analysis of membrane proteins remains complicated.
JRA3: Enabling integrative methodologies for cellular structural biology
iNEXT aims to make available to new communities the progress in different structural biology technology to address eukaryotic biomolecules and membrane proteins in native membranes, organelles and the cell envelope, also coupling in-cell research to in vitro biophysical methods.